                         SEQUENCE LISTING

<110>  IPSEN Pharma S.A.S.
       Biomeasure, Incorporated
       DONG, Zheng Xin
       ZHOU, Kevin L
       DeOLIVEIRA, Daniel B
 
<120>  Analogues of Neuropeptide Y Having At Least One Synthetic Amino 
       Acid Substitution

<130>  205P/PCT2

<150>  61/208151
<151>  2009-02-20

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  1

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Gln Arg Tyr 
        35      


<210>  2
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Generic Formula


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = Tyr, (X1,X2,X3,X4,X5)Phe, or HN-CH((CH2)n-N(R4R5))-C(O) 
       where X1-5 where each of X1, X2, X3, X4, and X5 is, independently
       for each occurrence, H, F, Cl, Br, I,(C1-10)alkyl, substitute, n 
       is 1-5, R4 and R5 are defined in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence, H, (C1-40)alkyl, 
       (C1-40)heteroalkyl, (C1-40)acyl, (C2-40)alkenyl, (C2-40)alkynyl, 
       aryl(C1-40)alkyl, aryl(C1-40)acyl, substituted (C1-40)alkyl, or

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence, substituted 
       (C1-40)heteroalkyl, substituted (C1-40)acyl, substituted 
       (C2-40)alkenyl, substituted (C2-40)alkynyl, or

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence, substituted aryl(C1-40)acyl, 
       (C1-40)alkylsulfonyl, or C(NH)-NH2, wherein when R4 is 
       (C1-40)acyl, aryl(C1-40)acyl, substituted (C1-40)acyl, or

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence,aryl(C1-40)acyl, substituted 
       (C1-40)acyl, substituted aryl(C1-40)acyl,substituted 
       aryl(C1-40)acyl,(C1-40)alkylsulfonyl, or

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence, C(NH)-NH2, then R5 is H or 
       (C1-C40)alkyl, (C1-40)heteroalkyl, (C2-40)alkenyl,(C2-40)alkynyl,
       aryl(C1-40)alkyl, or

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence,substituted (C1-40)alkyl, 
       substituted (C1-40)heteroalkyl, substituted (C2-40)alkenyl, 
       substituted (C2-40)alkynyl, or substituted aryl(C1-40)alkyl

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  (R2R3)-Xaa such that R2 and R3 each is, independently for each 
       occurrence, selected from the group consisting of substituted 
       (C1-30)alkyl, substituted (C1-30)heteroalkyl, 

       substituted (C2-30)acyl, substituted (C2-30)alkenyl, or

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  (R2R3)-Xaa such that R2 and R3 each is, independently for each 
       occurrence, selected from the group consisting of substituted  
       substituted (C2-30)alkynyl, substituted aryl(C1-30)alkyl, and 
       substituted aryl(C1-30)acyl

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  (R2R3)-Xaa such that R2 and R3 each is, independently for each 
       occurrence, selected from the group consisting of substituted  
       substituted (C2-30)alkynyl, substituted aryl(C1-30)alkyl, and 
       substituted aryl(C1-30)acyl; provided that

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  when R2 is (C1-30)acyl, aryl(C1-30)acyl, substituted (C2-30)acyl,
       or substituted aryl(C1-30)acyl, R3 is H, (C1-30)alkyl, 
       (C1-30)heteroalkyl, (C2-30)alkenyl, (C2-30)alkynyl, or

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  when R2 is aryl(C1-30)alkyl, substituted (C1-30)alkyl, 
       substituted (C1-30)heteroalkyl, substituted (C2-30)alkenyl, 
       substituted (C2-30)alkynyl, or substituted aryl(C1-30)alkyl

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa =  Pro, trans-3-hydroxy-L-proline (3Hyp), 
       cis-3-hydroxy-L-proline (cis-3Hyp), 4-hydroxyproline (4Hyp) or 
       cis-4-hydroxy-L-proline (cis-4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  Ser, alpha-aminobutyric acid (Abu), alpha-aminoisobutyric 
       acid (Aib), Ala Thr or HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5,
       R4 and R5 are defined in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each 
       is,independently for each occurrence, H, (C1-40)alkyl, 
       (C1-40)heteroalkyl, (C1-40)acyl, (C2-40)alkenyl, (C2-40)alkynyl, 
       aryl(C1-40)alkyl, aryl(C1-40)acyl, substituted (C1-40)alkyl, or

<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each 
       is,independently for each occurrence, substituted 
       (C1-40)heteroalkyl, substituted (C1-40)acyl, substituted 
       (C2-40)alkenyl, substituted (C2-40)alkynyl, or

<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each 
       is,independently for each occurrence,substituted 
       aryl(C1-40)alkyl,substituted aryl(C1-40)acyl, 
       (C1-40)alkylsulfonyl, or C(NH)-NH2, wherein when R4 is 
       

<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence,aryl(C1-40)acyl, substituted 
       (C1-40)acyl, substituted aryl(C1-40)acyl,substituted 
       aryl(C1-40)acyl,(C1-40)alkylsulfonyl, or

<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence, C(NH)-NH2, then R5 is H or 
       (C1-C40)alkyl, (C1-40)heteroalkyl, (C2-40)alkenyl,(C2-40)alkynyl,
       aryl(C1-40)alkyl, or

<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence,substituted (C1-40)alkyl, 
       substituted (C1-40)heteroalkyl, substituted (C2-40)alkenyl, 
       substituted (C2-40)alkynyl, or substituted aryl(C1-40)alkyl

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa =  Lys, Arg, homoarginine (hArg), 2,4-diaminobutyric acid 
       (Dab), 2,3-diaminopropionic acid (Dap), ornithine (Orn) or 
       HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 and R5 are defined 
       in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa =  Pro, trans-3-hydroxy-L-proline (3Hyp), 
       cis-3-hydroxy-L-proline (cis-3Hyp), 4-hydroxyproline (4Hyp) or 
       cis-4-hydroxy-L-proline (cis-4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each 
       is,independently for each occurrence, H, (C1-40)alkyl, 
       (C1-40)heteroalkyl, (C1-40)acyl, (C2-40)alkenyl, (C2-40)alkynyl, 
       aryl(C1-40)alkyl, aryl(C1-40)acyl, substituted (C1-40)alkyl, or

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each 
       is,independently for each occurrence, substituted 
       (C1-40)heteroalkyl, substituted (C1-40)acyl, substituted 
       (C2-40)alkenyl, substituted (C2-40)alkynyl, or

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each 
       is,independently for each occurrence,substituted 
       aryl(C1-40)alkyl,substituted aryl(C1-40)acyl, 
       (C1-40)alkylsulfonyl, or C(NH)-NH2, wherein when R4 is 
       

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence,aryl(C1-40)acyl, substituted 
       (C1-40)acyl, substituted aryl(C1-40)acyl,substituted 
       aryl(C1-40)acyl,(C1-40)alkylsulfonyl, or

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence, C(NH)-NH2, then R5 is H or 
       (C1-C40)alkyl, (C1-40)heteroalkyl, (C2-40)alkenyl,(C2-40)alkynyl,
       aryl(C1-40)alkyl, or

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence,substituted (C1-40)alkyl, 
       substituted (C1-40)heteroalkyl, substituted (C2-40)alkenyl, 
       substituted (C2-40)alkynyl, or substituted aryl(C1-40)alkyl

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa =  Asn, alpha-aminoisobutyric acid (Aib), Gln or  
       HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 and R5 are defined 
       in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa =  Pro, trans-3-hydroxy-L-proline (3Hyp), 
       cis-3-hydroxy-L-proline (cis-3Hyp), 4-hydroxyproline (4Hyp) or 
       cis-4-hydroxy-L-proline (cis-4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa =  Gly, alpha-aminoisobutyric acid (Aib) or 
       HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 and R5 are defined 
       in USSN  61/208153

<220>
<221>  MISC_FEATURE
<222>  (9)..(12)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each 
       is,independently for each occurrence, H, (C1-40)alkyl, 
       (C1-40)heteroalkyl, (C1-40)acyl, (C2-40)alkenyl, (C2-40)alkynyl, 
       aryl(C1-40)alkyl, aryl(C1-40)acyl, substituted (C1-40)alkyl, or

<220>
<221>  MISC_FEATURE
<222>  (9)..(12)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each 
       is,independently for each occurrence, substituted 
       (C1-40)heteroalkyl, substituted (C1-40)acyl, substituted 
       (C2-40)alkenyl, substituted (C2-40)alkynyl, or

<220>
<221>  MISC_FEATURE
<222>  (9)..(12)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each 
       is,independently for each occurrence,substituted 
       aryl(C1-40)alkyl,substituted aryl(C1-40)acyl, 
       (C1-40)alkylsulfonyl, or C(NH)-NH2, wherein when R4 is 
       

<220>
<221>  MISC_FEATURE
<222>  (9)..(12)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence,aryl(C1-40)acyl, substituted 
       (C1-40)acyl, substituted aryl(C1-40)acyl,substituted 
       aryl(C1-40)acyl,(C1-40)alkylsulfonyl,or

<220>
<221>  MISC_FEATURE
<222>  (9)..(12)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence, C(NH)-NH2, then R5 is H or 
       (C1-C40)alkyl, (C1-40)heteroalkyl, (C2-40)alkenyl,(C2-40)alkynyl,
       aryl(C1-40)alkyl, or

<220>
<221>  MISC_FEATURE
<222>  (9)..(12)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence,substituted (C1-40)alkyl, 
       substituted (C1-40)heteroalkyl, substituted (C2-40)alkenyl, 
       substituted (C2-40)alkynyl, or substituted aryl(C1-40)alkyl

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa =   Glu, alpha-aminoisobutyric acid (Aib), Asn, Asp, Gln or  
       HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 and R5 are defined 
       in USSN        61/208153

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa =   Asp, alpha-aminoisobutyric acid (Aib), Asn, Gln, Glu or  
       HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 and R5 are defined 
       in USSN        61/208153

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa =   Ala, alpha-aminobutyric acid (Abu), alpha-aminoisobutyric
       acid (Aib),  norvaline (Nva), Val or HN-CH((CH2)n-N(R4R5))-C(O) 
       where n is 1-5, R4 and R5 are defined in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa =  Pro, trans-3-hydroxy-L-proline (3Hyp), 
       cis-3-hydroxy-L-proline (cis-3Hyp), 4-hydroxyproline (4Hyp) or 
       cis-4-hydroxy-L-proline (cis-4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa =   Ala, alpha-aminobutyric acid (Abu), alpha-aminoisobutyric
       acid (Aib),  norvaline (Nva), Val or HN-CH((CH2)n-N(R4R5))-C(O) 
       where n is 1-5, R4 and R5 are defined in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (14)..(37)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each 
       is,independently for each occurrence, H, (C1-40)alkyl, 
       (C1-40)heteroalkyl, (C1-40)acyl, (C2-40)alkenyl, (C2-40)alkynyl, 
       aryl(C1-40)alkyl, aryl(C1-40)acyl, substituted (C1-40)alkyl, or

<220>
<221>  MISC_FEATURE
<222>  (14)..(37)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each 
       is,independently for each occurrence, substituted 
       (C1-40)heteroalkyl, substituted (C1-40)acyl, substituted 
       (C2-40)alkenyl, substituted (C2-40)alkynyl, or

<220>
<221>  MISC_FEATURE
<222>  (14)..(37)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each 
       is,independently for each occurrence,substituted 
       aryl(C1-40)alkyl,substituted aryl(C1-40)acyl, 
       (C1-40)alkylsulfonyl, or C(NH)-NH2, wherein when R4 is 
       

<220>
<221>  MISC_FEATURE
<222>  (14)..(37)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence,aryl(C1-40)acyl, substituted 
       (C1-40)acyl, substituted aryl(C1-40)acyl,substituted 
       aryl(C1-40)acyl,(C1-40)alkylsulfonyl,or

<220>
<221>  MISC_FEATURE
<222>  (14)..(37)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence, C(NH)-NH2, then R5 is H or 
       (C1-C40)alkyl, (C1-40)heteroalkyl, (C2-40)alkenyl,(C2-40)alkynyl,
       aryl(C1-40)alkyl, or

<220>
<221>  MISC_FEATURE
<222>  (14)..(37)
<223>  HN-CH((CH2)n-N(R4R5))-C(O) such that R4 and R5 each is, 
       independently for each occurrence,substituted (C1-40)alkyl, 
       substituted (C1-40)heteroalkyl, substituted (C2-40)alkenyl, 
       substituted (C2-40)alkynyl, or substituted aryl(C1-40)alkyl

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa =   Glu, alpha-aminoisobutyric acid (Aib), Asn, Asp, Gln or  
       HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 and R5 are defined 
       in USSN       61/208153

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa =   Asp, alpha-aminoisobutyric acid (Aib), Asn, Gln, Glu or  
       HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 and R5 are defined 
       in USSN       61/208153

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = Met, 1-amino-1-cyclo(C3-9)alkyl carboxylic acid (Acc), 
       alpha-aminoisobutyric acid (Aib), beta-cyclohexylalanine (Cha), 
       Ile, Leu, homo-, nor-, tert-leucine (hLeu, Nle,Tle), norvaline 
       (Nva), Val or

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 and R5 are 
       defined in USSN   61/208153

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa =   Ala, alpha-aminobutyric acid (Abu), alpha-aminoisobutyric
       acid (Aib),  norvaline (Nva), Val or HN-CH((CH2)n-N(R4R5))-C(O) 
       where n is 1-5, R4 and R5 are defined in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa = Arg, homoarginine (hArg), 4-amino-4-carboxypiperidine 
       (Apc), 2,4-diaminobutyric acid (Dab), 2,3-diaminopropionic acid 
       (Dap), Lys, ornithine (Orn) or HN-CH((CH2)n-N(R4R5))-C(O) where n
       is 1-5, R4 and R5 are defined in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (20)..(21)
<223>  Xaa = Tyr, (X1,X2,X3,X4,X5)Phe, or HN-CH((CH2)n-N(R4R5))-C(O) 
       where X1-5, n is 1-5, R4 and R5 are defined in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = Ser, alpha-aminobutyric acid (Abu), alpha-aminoisobutyric 
       acid (Aib), Ala, Thr or HN-CH((CH2)n-N(R4R5))-C(O) where n is 
       1-5, R4 and R5 are defined in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa = Ala, alpha-aminobutyric acid (Abu), alpha-aminoisobutyric 
       acid (Aib),  norvaline (Nva), Val or  HN-CH((CH2)n-N(R4R5))-C(O) 
       where n is 1-5, R4 and R5 are defined in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = Leu, 1-amino-1-cyclo(C3-9)alkyl carboxylic acid (Acc), 
       beta-cyclohexylalanine (Cha), Ile, homoleucine (hLeu), norleucine
       Nle), norvaline (Nva), tert-leucine (Tle), Val or

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 and R5 are 
       defined in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = Arg, homoarginine (hArg), 4-amino-4-carboxypiperidine 
       (Apc), 2,4-diaminobutyric acid (Dab), 2,3-diaminopropionic acid 
       (Dap), Lys, ornithine (Orn) or HN-CH((CH2)n-N(R4R5))-C(O) where n
       is 1-5, R4 and R5 are defined in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa = His, beta-(2-pyridyl)alanine (2Pal), 
       beta-(3-pyridyl)alanine (3Pal), beta-(4-pyridyl)alanine (4Pal) or
       HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 and R5 are defined 
       in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa = Tyr, (X1,X2,X3,X4,X5)Phe, or HN-CH((CH2)n-N(R4R5))-C(O) 
       where X1-5, n is 1-5, R4 and R5 are defined in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = Ile, 1-amino-1-cyclo(C3-9)alkyl carboxylic acid (Acc), 
       beta-cyclohexylalanine (Cha), Leu, homoleucine (hLeu), norleucine
       (Nle), norvaline (Nva), tertleucine (Tle), Val or

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 and R5 are 
       defined in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa =  Asn, alpha-aminoisobutyric acid (Aib), Gln or 
       HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 and R5 are defined 
       in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa = Leu, 1-amino-1-cyclo(C3-9)alkyl carboxylic acid (Acc), 
       beta-cyclohexylalanine (Cha), Ile, homoleucine (hLeu), norleucine
       (Nle), norvaline (Nva), tert-leucine (Tle), Val or

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa = HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 and R5 are 
       defined in USSN

61/20815

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa = HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5 R4 and R5 are 
       defined in USSN  61/20815

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa = Ile, 1-amino-1-cyclo(C3-9)alkyl carboxylic acid (Acc), 
       beta-cyclohexylalanine (Cha), Leu, homoleucine (hLeu), norleucine
       (Nle), norvaline (Nva), tertleucine (Tle), Val or

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa = Thr, alpha-aminoisobutyric acid (Aib), Ser or 
       HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 and R5 are defined 
       in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa = Arg, homoarginine (hArg), 4-amino-4-carboxypiperidine 
       (Apc), 2,4-diaminobutyric acid (Dab), 2,3-diaminopropionic acid 
       (Dap), Lys, ornithine (Orn) or HN-CH((CH2)n-N(R4R5))-C(O) where n
       is 1-5, R4 and R5 are defined in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = Gln, Asn, 3,4-dehydroproline (Dhp), 
       trans-3-hydroxy-L-proline (3Hyp), cis-3-hydroxy-L-proline 
       (cis-3Hyp), 4-hydroxyproline (4Hyp), cis-4-hydroxy-L-proline 
       (cis-4Hyp), isonipecotic acid (Inp), or

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-ketoproline (Ktp), nipecotic acid (Nip), 
       octahydroindole-2-carboxylic acid (Oic), Pro, homoproline (hPro),
       1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) or 
       HN-CH((CH2)0-5-N(R2R3))-C(O) where

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = where each of R2 and R3 is, independently for each 
       occurrence, H, (C1-40)alkyl, (C1-40)heteroalkyl, (C1-40)acyl, 
       (C2-40)alkenyl, or

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa =  where each of R2 and R3 is, independently for each 
       occurrence, (C2-40)alkynyl, aryl(C1-40)alkyl, aryl(C1-40)acyl, 
       substituted (C1-40)alkyl, substituted (C1-40)heteroalkyl, 
       substituted (C1-40)acyl, or

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa =  where each of R2 and R3 is, independently for each 
       occurrence, substituted (C2-40)alkenyl, substituted 
       (C2-40)alkynyl, substituted aryl(C1-40)alkyl, substituted 
       aryl(C1-40)acyl, or

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa =  where each of R2 and R3 is, independently for each 
       occurrence, (C1-40)alkylsulfonyl, or C(NH)-NH2, wherein when R2 
       is (C1-40)acyl, aryl(C1-40)acyl, substituted (C1-40)acyl, or

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa =  wherein when R2 is substituted aryl(C1-40)acyl, 
       (C1-40)alkylsulfonyl, or C(NH)-NH2, then R3 is H or 
       (C1-C40)alkyl, (C1-40)heteroalkyl, (C2-40)alkenyl,

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa =  then R3 is (C2-40)alkynyl, aryl(C1-40)alkyl, substituted 
       (C1-40)alkyl, substituted (C1-40)heteroalkyl, substituted 
       (C2-40)alkenyl, substituted (C2-40)alkynyl, or substituted 
       aryl(C1-40)alkyl.

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa = Arg, Aic, Apc, hArg, Dab, Dap, Lys, Orn, NH2Phe, NH2CH2Phe,
       or  HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 and R5 are 
       defined in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (35)..(36)
<223>  Xaa = Tyr, Aic, (X1,X2,X3,X4,X5)Phe,or  
       HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 and R5 are defined 
       in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa = Deleted or  HN-CH((CH2)n-N(R4R5))-C(O) where n is 1-5, R4 
       and R5 are defined in USSN 61/208153

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa-R1 such that R1 is OH, NH2, (C1-30)alkoxy, or NH-X6-CH2-X7, 
       wherein X6 is a (C1-40)alkyl or  (C2-40)alkenyl, and wherein X7 
       is H, OH, CO2H, or C(O)-NH2

<400>  2

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa 
        35          


<210>  3
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  3

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Xaa Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  4
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  4

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  5
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  5

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Xaa Ala Pro Ala Glu Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  6
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  6

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  7
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  7

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Xaa Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  8
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  8

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Xaa Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  9
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  9

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Xaa Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  10
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  10

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Xaa Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  11
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  11

Tyr Pro Xaa Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  12
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  12

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Xaa Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  13
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  13

Tyr Pro Ser Lys Pro Xaa Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  14
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  14

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Xaa Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  15
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  15

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Xaa Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  16
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  16

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Xaa 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  17
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  17

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Xaa Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  18
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  18

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  19
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  19

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Xaa Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  20
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  20

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Xaa Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  21
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  21

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Xaa Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  22
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  22

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Xaa Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  23
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  23

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Xaa 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  24
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  24

Tyr Pro Ser Lys Pro Asp Xaa Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  25
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  25

Tyr Pro Ser Lys Pro Asp Asn Pro Xaa Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  26
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  26

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Xaa Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  27
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  27

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Xaa Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  28
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  28

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Xaa Ala Pro Ala Xaa Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  29
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  29

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Xaa Asp Ala Pro Ala Xaa Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  30
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  30

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Xaa Ala Pro Ala Xaa Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  31
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  31

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Xaa Pro Ala Xaa Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  32
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  32

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Xaa Asp Ala Pro Ala Xaa Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  33
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  33

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Xaa Ala Pro Ala Glu Xaa 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  34
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  34

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Xaa Asp Ala Pro Ala Glu Xaa 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  35
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (35)..(36)
<223>  N-acetylated reduced peptide bond

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  35

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Xaa Ala Pro Ala Glu Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Lys Tyr 
        35      


<210>  36
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa = 4-amino-4-carboxypiperidine (Apc)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  36

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Xaa Tyr 
        35      


<210>  37
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa = 2-aminoindan-2-carboxylic acid (Aic)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  37

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Xaa 
        35      


<210>  38
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa = 4NH2Phe

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  38

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Xaa Tyr 
        35      


<210>  39
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa = 4NH2CH2Phe

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  39

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Xaa Tyr 
        35      


<210>  40
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (35)..(36)
<223>  reduced peptide bond

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  40

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Lys Tyr 
        35      


<210>  41
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (35)..(36)
<223>  reduced peptide bond

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  41

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Xaa Ala Pro Ala Glu Asp 
1               5                   10                  15      


Xaa Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Lys Tyr 
        35      


<210>  42
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = nipecotic acid (Nip)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  42

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  43
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = isonipecotic acid (Inp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  43

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  44
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 3,4-dehydroproline (Dhp)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  44

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  45
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = homoproline (hPro)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  45

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  46
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa = 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  46

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Xaa Arg Tyr 
        35      


<210>  47
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  C(O)-(CH2)12-CH3 coupled to the epsilon-nitrogen of the Lys 
       sidechain

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  47

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Leu Thr 
            20                  25                  30          


Arg Lys Arg Tyr 
        35      


<210>  48
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic analog of NPY


<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  AMIDATION

<400>  48

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Pro Arg Tyr 
        35      


<210>  49
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  49

Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile Thr 
            20                  25                  30          


Arg Gln Arg Tyr 
        35      


